Log In
Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum.
Abstract
BACKGROUND
Fissistigma polyanthum is a liane belonging to the Annonaceae family and it is one of the most important crude drugs in traditional
Chinese medicine.
OBJECTIVE
The objective was to describe the structural elucidation and the free-radical-scavenging activities of the isolated compounds
from Fissistigma polyanthum.
MATERIAL AND METHODS
The chemical constituents were isolated and purified by normal, reverse column chromatography and HPLC. Their structures were
identified by spectroscopic methods ((1)H NMR and (13)C NMR) and by comparison with literature values, and the free-radical-scavenging
activities of these two compounds were also evaluated through three in vitro model systems (DPPH, trolox equivalent antioxidant
capacity (TEAC) and Co (II) EDTA-induced luminol chemiluminescence by flow injection).
RESULTS
Two known compounds, named kanakugiol (1) and teutenone A (2), were isolated from the stem of Fissistigma polyanthum for the
first time, and compound 1 exhibited moderate free-radical-scavenging activity.
CONCLUSION
Fissistigma polyanthum, which has traditionally been used as an important Chinese medicine, showed a certain free-radical-scavenging
activity.
Links
Authors
Fan H, Zheng T, Chen Y, Yang GZ
Institution
Department of Natural Products, College of Pharmacy, South Central University for Nationalities, Wuhan, P.R., China.
Source
Pharmacognosy magazine 8:30 2012 Apr pg 98-102Pub Type(s)
Journal ArticleLanguage
eng
PubMed ID
22701280