Isolation and structure determination of new siderophore tsukubachelin B from Streptomyces sp. TM-74.
The new siderophore tsukubachelin B (1) was isolated from the iron-deficient culture medium of the newly isolated strain Streptomyces sp. TM-74. The chemical structure of tsukubachelin B (1) was established via interpretation of 2D nuclear magnetic resonance and electrospray ionization-mass spectroscopic data. The structure of tsukubachelin B (1) comprises 6 mol of amino acids, including 2 mol of serine and 1 mol each of ornithine, N-α-methyl-N-δ-hydroxy-N-δ-formylornithine, N-α-methyl-N-δ-hydroxyornithine, and cyclic N-hydroxyornithine.
a Department of Applied Biological Chemistry, Faculty of Agriculture , Shizuoka University , 836 Ohya, Suruga-ku , Shizuoka 422-8529 , Japan.
SourceNatural product research 27:9 2013 May pg 775-81
Pub Type(s)Journal Article