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Interleukin-6 and melanoma.

Abstract

Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6 is deregulated in many types of cancers, and increased serum concentration of IL-6 has been correlated with a worse prognosis in patients with different cancers, including melanoma. Several serum cytokines including IL-6 play an important role in the development and progression of melanoma; however, the specific biological functions of IL-6 in progression of melanoma are unknown. In this review, we present studies on cell cultures and mouse models and summarize published clinical studies on IL-6 and melanoma.

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  • Publisher Full Text
  • Authors

    Hoejberg L, Bastholt L, Schmidt H

    Source

    Melanoma research 22:5 2012 Oct pg 327-33

    MeSH

    Animals
    Cell Line, Tumor
    Disease Models, Animal
    Disease Progression
    Humans
    Interleukin-6
    Melanoma
    Mice
    Mice, Transgenic
    Prognosis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22713796