Abstract

There is now strong evidence that mutation not only abrogates p53 tumor-suppressive functions, but in some instances can also endow mutant proteins with novel activities. Such neomorphic p53 proteins are capable of dramatically altering tumor cell behavior, primarily through their interactions with other cellular proteins and regulation of cancer cell transcriptional programs. Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. Here we review mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeoning mutant p53 transcriptome, and discuss the biological and clinical consequences of mutant p53 gain of function.

Links

PMC Free PDF

Publisher Full Text

Authors

Freed-Pastor WA, Prives C

Institution

Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Source

Genes & development 26:12 2012 Jun 15 pg 1268-86

MeSH

Humans
Models, Biological
Mutant Proteins
Neoplasms
Proto-Oncogene Proteins
Transcription, Genetic
Tumor Suppressor Protein p53

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22713868