Abstract

OBJECTIVES
The aim of the study was to determine the prevalence of hyper and hypo-parathyroid state in prevalent dialysis patients. The second part of the study was to look for the prevalence of vascular calcification (abdominal aortic) and factors predicting calcification in these patients.
METHODS
All adult patients, who were more than 1 month on dialysis, were included in the study. A total of 68 patients, of which 75% were on hemodialysis and 25% on peritoneal dialysis, were finally studied. Patients' parathyroid status was defined as per target recommendation of KDOQI--hypoparathyroid with iPTH < or = 150 pg/ml and hyperparathyroid with iPTH > 300 pg/ml. Vascular calcification was determined by X ray of lateral lumbar spine to look for abdominal aortic calcification (AAC). The AAC was scored as validated. The prevalence of hyper- and hypoparathyroidism in dialysis patients was determined as percentage of total dialysis patients. The prevalence of AAC and factors predicting it was analyzed by 'univariate' and 'multiple logistic regression analyses.
RESULTS
The mean age of patients was 50.04 +/- 14.15 years, 58.82% were males and 42.64% were diabetics. Mean duration of dialysis was 22.36 +/- 19.17 months. Hyperparathyroidism was seen in only 27.94% of all dialysis patients, while hypoparathyroidism was in 45.58%. Abdominal aortic calcification was seen in 79.41% of overall patients and 13.23% had significant calcification (score 7-24). On univariate analysis, age (0.000) and iPTH (0.03) were the only variables predicting AAC and on logistic regression analysis, age was the only independent predictor of abdominal aortic calcification (p = 0.002, OR 1.11, CI 1.038-1.186).
CONCLUSION
Hypoparathyroidism is more common (46%) in our dialysis patients as compared to hyperparathyroidism (28%). There is high prevalence of vascular (abdominal aortic) calcification (80%) in our dialysis patients.

Authors

Jeloka T, Mali M, Jhamnani A, Konde S, Jadhav V

Institution

Dept of Nephrology, Aditya Birla Memorial Hospital, Pune.

Source

The Journal of the Association of Physicians of India 60: 2012 Feb pg 102-5

MeSH

Adult
Aged
Aged, 80 and over
Alkaline Phosphatase
Aorta, Abdominal
Calcium
Female
Humans
Hyperparathyroidism, Secondary
Hypoparathyroidism
India
Kidney Failure, Chronic
Logistic Models
Lumbar Vertebrae
Male
Middle Aged
Parathyroid Hormone
Phosphates
Prevalence
Renal Dialysis
Risk Factors
Vascular Calcification

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22715556