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Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma.

Abstract

AIMS
To establish whether microscopic angiotropism of melanoma cells correlates with microscopic satellite (MS) formation in cutaneous melanomas and thus is likely to explain the development of MS.
MATERIALS AND RESULTS
Patients with MS and controls without MS from 1996 to 2009 were evaluated for the presence or absence of angiotropism. MS was defined as a dermal/subcutaneous tumour nodule >0.05 mm, separated from the primary tumour by at least 0.3 mm. Forty four cases and controls were matched for tumour thickness, mitotic rate, ulceration, age, gender and primary site. Angiotropism (23 of 44, 52%) and absent regression (19 of 44, 43%) were significantly more frequent in melanomas with MS than in those without MS (controls) (12 of 44, 27%) (P = 0.017) and (32 of 44, 73%) (P = 0.005), respectively. Factors correlating with angiotropism included increased Clark level (P = 0.046), regression absence (P = 0.02) and MS (P = 0.017). On multivariable analysis, MS formation was predicted by angiotropism (P = 0.026), Clark level V (P = 0.01), absent regression (P = 0.009) and acral site (P = 0.02).
CONCLUSIONS
Angiotropism predicts MS development. These data provide additional evidence for the importance of angiotropism as a means of melanoma metastasis.

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  • Publisher Full Text
  • Authors

    Wilmott J, Haydu L, Bagot M, Zhang Y, Jakrot V, McCarthy S, Lugassy C, Thompson J, Scolyer R, Barnhill R

    Institution

    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

    Source

    Histopathology 61:5 2012 Nov pg 889-98

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Female
    Humans
    Male
    Melanoma
    Microvessels
    Middle Aged
    Neoplasm Invasiveness
    Neoplasm Micrometastasis
    Skin Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22716270