Abstract

Waldenström macroglobulinemia is a rare low-grade hematologic malignancy due to clonal proliferation of B lymphocytes responsible for immunoglobulin M (IgM) monoclonal gammopathy secreted in serum. This disease is characterized by lymphoplasmacytic tumoral infiltration of bone marrow and various organs, especially the liver and spleen. Kidney involvement in Waldenström macroglobulinemia has been described previously with reports of various forms of glomerular injury: large intracapillary IgM pseudothrombi, cryoglobulinemia-associated membranoproliferative glomerulonephritis, or amyloidosis. Interstitial infiltration by tumoral B lymphocytes is another classic pattern. Conversely, tubular involvement in the form of myeloma-like casts or basement membrane deposition of monoclonal light chain (light-chain deposition disease) is unusual. We report the occurrence of cast nephropathy associated with light-chain deposition disease in 2 patients with Waldenström macroglobulinemia, which resulted in severe and prolonged kidney failure.

Links

Publisher Full Text

Authors

Gnemmi V, Leleu X, Provot F, Moulonguet F, Buob D

Institution

Department of Pathology, CHU Lille, Lille, France. gnemmiviv@yahoo.fr

Source

American journal of kidney diseases : the official journal of the National Kidney Foundation 60:3 2012 Sep pg 487-91

MeSH

Aged
Aged, 80 and over
Amyloidosis
Biopsy, Needle
Disease Progression
Female
Follow-Up Studies
Humans
Immunoglobulin Light Chains
Immunohistochemistry
Kidney Failure, Chronic
Kidney Tubules
Male
Myeloma Proteins
Paraproteinemias
Renal Dialysis
Risk Assessment
Severity of Illness Index
Treatment Outcome
Waldenstrom Macroglobulinemia

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22721930