Abstract

OBJECTIVES
We measured the serum concentration of a panel of inflammatory cytokines and evaluated their association with circulating proangiogenic biomarkers and with outcome in patients with pancreatic ductal adenocarcinoma (PDAC).
METHODS
We collected serum samples from 36 patients with PDAC, 9 patients with chronic pancreatitis, and 22 healthy volunteers as a control. Inflammatory cytokines and proangiogenic biomarkers were measured using the multianalyte xMAP array and carcinoembryonic antigen (CEA) and carbohydrate 19-9 by immunoassay.
RESULTS
Patients with PDAC had higher circulating levels of interleukin 6 (IL-6) than those of patients with pancreatitis or healthy individuals and higher levels of IL-10 and tumor necrosis factor α (TNF-α) compared with those of healthy individuals. In patients with PDAC, circulating IL-6, TNF-α, IL-1β, and IL-10 correlated with serum concentrations of vascular endothelial growth factor and basic fibroblast growth factor; circulating IL-6, IL-1β, and TNF-α correlated with carbohydrate 19-9; and IL-8, IL-10, and TNF-α correlated with CEA levels. Circulating IL-8, TNF-α, and CEA; tumor stage; and lymph node metastases were associated with a poor outcome.
CONCLUSIONS
The results of this exploratory study indicate that inflammatory cytokines should be pursued as potential prognostic biomarkers as well as targets for therapy in larger studies in PDAC.

Links

Publisher Full Text

Authors

Dima SO, Tanase C, Albulescu R, Herlea V, Chivu-Economescu M, Purnichescu-Purtan R, Dumitrascu T, Duda DG, Popescu I

Institution

Center of Digestive Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.

Source

Pancreas 41:7 2012 Oct pg 1001-7

MeSH

Adult
Aged
CA-19-9 Antigen
Carcinoembryonic Antigen
Carcinoma, Pancreatic Ductal
Cytokines
Female
Fibroblast Growth Factor 2
Humans
Interleukin-10
Interleukin-1beta
Interleukin-6
Macrophages
Male
Middle Aged
Pancreatic Neoplasms
Prognosis
Tumor Markers, Biological
Tumor Necrosis Factor-alpha
Vascular Endothelial Growth Factor A

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22722257