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Drosophila as a model system to unravel the layers of innate immunity to infection.

Abstract

Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host-pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.

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    • Authors

    Kounatidis I, Ligoxygakis P

    Institution

    Laboratory of Genes and Development, Department of Biochemistry , University of Oxford , South Parks Road, Oxford OX1 3QU , UK.

    Source

    Open biology 2:5 2012 May pg 120075

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22724070