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Common carotid flow velocity is associated with cognition in older adults.

Abstract

AIMS
To assess the relationship between carotid flow velocity and cognitive impairment in patients with mild-moderate (<50%) carotid artery disease.
METHODS
We studied 407 participants with available carotid ultrasound and cognitive measures. We related peak systolic velocity (PSV) and end diastolic velocity (EDV) of internal carotid artery (ICA) and common carotid artery (CCA) and intimal medial thickness (IMT) to Mini Mental State Examination (MMSE), Clock Draw Test (CDT), Activities of Daily Living Scale (ADL)and Montreal Cognitive Assessment (MoCA).
RESULTS
EDV of CCA was significantly different in higher and lower MoCA (MMSE) groups. Multiple regression analysis demonstrated that lower EDV was significantly associated with lower MoCA (+0.459 per standard deviation (SD), p<0. 01 for the left; +0.539 per SD, p<0. 01 for the right) and CDT (odds ratio (OR) 0.093, p< 0.05 for the left; OR) 0.120, p<0. 01 for the right) scores. PSV of left CCA (-0.205 per SD, p<0.05) and IMT (+42.536 per SD, p< 0.001) were associated with ADL. PSV of right CCA was associated with MMSE (+0.081 per SD, p<0.001). No significant relationship between ICA flow velocity and cognitive performance was observed.
CONCLUSIONS
Our preliminary data show that common carotid artery flow velocity was associated with cognitive performance.

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  • Authors

    Fu GX, Miao Y, Yan H, Zhong Y

    Institution

    Department of Gerontology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

    Source

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 39:4 2012 Jul pg 502-7

    MeSH

    Activities of Daily Living
    Aged
    Blood Flow Velocity
    Carotid Arteries
    Carotid Artery Diseases
    Cognition Disorders
    Female
    Humans
    Male
    Mental Status Schedule
    Middle Aged
    Neuropsychological Tests
    Regression Analysis
    Ultrasonography, Doppler, Duplex

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22728859