Anti HIV-1 agents 6. Synthesis and anti-HIV-1 activity of indolyl glyoxamides.
In order to discover compounds with superior anti-human immunodeficiency virus type 1 (HIV-1) activity, 9 new indolyl glyoxamide derivatives (3a-i) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 3e and 3h showed the potent anti-HIV-1 activity with EC(50) values of 6.83 and 4.35 µg/mL, and TI values of >27.15 and 49.45, respectively. It demonstrated that introduction of the substituent R(3) as the halogen atom and the position of R(3) were generally important to their activity.
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, PR China.
SourceMedicinal chemistry (Shāriqah (United Arab Emirates)) 8:5 2012 Sep pg 831-3
HIV Protease Inhibitors
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't