Unbound MEDLINE

Hypersensitivity reactions to proton pump inhibitors.

Abstract

PURPOSE OF REVIEW
Proton pump inhibitors (PPI) are one of most frequently prescribed drugs in the world. The purpose of this review is to describe the hypersensitivity reactions to PPI.
RECENT FINDINGS
Hypersensitivity reactions to PPI vary from mild symptoms to life-threatening disorders. Cases of urticaria, angioedema, anaphylaxis, cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis, and other autoimmune reactions (including cutaneous lupus erythematosus) have been described.
SUMMARY
A high level of clinical suspicion is critical in the diagnosis of PPI-induced hypersensitivity reactions. Physicians should be aware of the possible hypersensitivity reactions due to PPI and routine/empirical prescription for PPI should only be used when clinically indicated.

Links

  • Publisher Full Text

    • Authors

    Chang YS

    Institution

    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. addchang@snu.ac.kr

    Source

    Current opinion in allergy and clinical immunology 12:4 2012 Aug pg 348-53

    MeSH

    Acute Disease
    Anaphylaxis
    Angioedema
    Dermatitis, Exfoliative
    Dermatitis, Photoallergic
    Drug Hypersensitivity
    Eosinophilia
    Female
    Humans
    Lupus Erythematosus, Cutaneous
    Male
    Nephritis, Interstitial
    Proton Pump Inhibitors
    Stevens-Johnson Syndrome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22744268