Abstract

Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH(2), OH, Br, F, and SiMe(3) groups remain intact during the reaction.

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Publisher Full Text

Authors

Fan BM, Yang QJ, Hu J, Fan CL, Li SF, Yu L, Huang C, Tsang WW, Kwong FY

Institution

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming, 650500, China. adams.bmf@hotmail.com

Source

Angewandte Chemie (International ed. in English) 51:31 2012 Jul 27 pg 7821-4

MeSH

Alkynes
Bridged Compounds
Catalysis
Iridium
Molecular Structure
Norbornanes
Organometallic Compounds
Stereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22744889