Asymmetric hydroalkynylation of norbornadienes promoted by chiral iridium catalysts.
Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH(2), OH, Br, F, and SiMe(3) groups remain intact during the reaction.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming, 650500, China. email@example.com
SourceAngewandte Chemie (International ed. in English) 51:31 2012 Jul 27 pg 7821-4
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't