Unbound MEDLINE

Asymmetric hydroalkynylation of norbornadienes promoted by chiral iridium catalysts.

Abstract

Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH(2), OH, Br, F, and SiMe(3) groups remain intact during the reaction.

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  • Publisher Full Text
  • Authors

    Fan BM, Yang QJ, Hu J, Fan CL, Li SF, Yu L, Huang C, Tsang WW, Kwong FY

    Institution

    Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming, 650500, China. adams.bmf@hotmail.com

    Source

    Angewandte Chemie (International ed. in English) 51:31 2012 Jul 27 pg 7821-4

    MeSH

    Alkynes
    Bridged Compounds
    Catalysis
    Iridium
    Molecular Structure
    Norbornanes
    Organometallic Compounds
    Stereoisomerism

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22744889