Unbound MEDLINE

Asymmetric hydroalkynylation of norbornadienes promoted by chiral iridium catalysts.

Abstract

Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH(2), OH, Br, F, and SiMe(3) groups remain intact during the reaction.

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  • Publisher Full Text
  • Authors

    Fan BM, Yang QJ, Hu J, Fan CL, Li SF, Yu L, Huang C, Tsang WW, Kwong FY

    Source

    Angewandte Chemie (International ed. in English) 51:31 2012 Jul 27 pg 7821-4

    MeSH

    Alkynes
    Bridged Compounds
    Catalysis
    Iridium
    Molecular Structure
    Norbornanes
    Organometallic Compounds
    Stereoisomerism

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22744889