Unbound MEDLINE

Acute liver failure related to chemotherapy.

Abstract

Hepatitis B virus (HBV) reactivation is a serious but preventable complication of immunosuppression. Chemotherapy in patients with lymphoma without specific anti-HBV prophylaxis leads to significant impairment of liver function and results in an overall liver-related mortality of greater than 5%. Prevention is a better approach than intervention at the time of reactivation. The cause of death is usually HBV-related fulminant liver failure. We reported a case of a male patient aged 42 years old who was present with acute liver failure related to chemotherapy for treatment of gastric lymphoma. He was later known as having chronic carrier hepatitis B, with high elevated transaminases and hyperbilirubinemia and signs of decompensated liver. The patient was admitted to High Care Unit for best supportive care but his condition was deteriorating and eventually died eventhough he had been already given antiviral agent.

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  • Publisher Full Text
  • Authors

    Wijaya I, Sanityoso A, Lesmana LA

    Institution

    Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital. Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia. leon_natan@yahoo.com

    Source

    Acta medica Indonesiana 44:2 2012 Apr pg 145-9

    MeSH

    Adult
    Antibodies, Monoclonal, Murine-Derived
    Antineoplastic Combined Chemotherapy Protocols
    Cyclophosphamide
    Doxorubicin
    Fatal Outcome
    Hepatitis B virus
    Hepatitis B, Chronic
    Humans
    Liver Failure, Acute
    Lymphoma, Non-Hodgkin
    Male
    Prednisone
    Stomach Neoplasms
    Vincristine
    Virus Activation

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    22745146