Regional astrocyte allocation regulates CNS synaptogenesis and repair.
Astrocytes, the most abundant cell population in the central nervous system (CNS), are essential for normal neurological function. We show that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of origin in the ventricular zone. These domains remain stable throughout life without evidence of secondary tangential migration, even after acute CNS injury. Domain-specific depletion of astrocytes in ventral spinal cord resulted in abnormal motor neuron synaptogenesis, which was not rescued by immigration of astrocytes from adjoining regions. Our findings demonstrate that region-restricted astrocyte allocation is a general CNS phenomenon and reveal intrinsic limitations of the astroglial response to injury.
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.
SourceScience (New York, N.Y.) 337:6092 2012 Jul 20 pg 358-62
Basic Helix-Loop-Helix Transcription Factors
Green Fluorescent Proteins
Nerve Tissue Proteins
Spinal Cord Injuries
Pub Type(s)Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't