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Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis.

Abstract

OBJECTIVES
Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis.
METHODS
We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011.
RESULTS
There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia.
CONCLUSIONS
Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.

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    • Authors

    Kishi T, Fukuo Y, Okochi T, Kawashima K, Kitajima T, Inada T, Ozaki N, Musso GM, Kane JM, Correll CU, Iwata N

    Institution

    Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA. tarok@fujita-hu.ac.jp

    Source

    Human psychopharmacology 27:1 2012 Jan pg 63-9

    MeSH

    Adult
    Case-Control Studies
    Female
    Genetic Predisposition to Disease
    Genotype
    Haplotypes
    Humans
    Japan
    Male
    Middle Aged
    Polymorphism, Single Nucleotide
    Receptors, Serotonin
    Schizophrenia

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22745941