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The hypoglycemic effects of American red ginseng (Panax quinquefolius L.) on a diabetic mouse model.

Abstract

American ginseng (Panax quinquefolius L.) root health benefits include treatment of type 2 diabetes and this study evaluated the hypoglycemic effects of American red ginseng (ARG). ARG roots have increased bioactive phenolic contents, such as cinnamic acid and ferulic acid during the steaming process. The antihyperglycemic effects of methanol fraction extract of ARG, ferulic acid, and cinnamic acid were examined using a type 2 diabetic mouse model. The ARG treated group presented relatively lower blood glucose levels than the control group (P < 0.05). In addition, the glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. The groups treated with ferulic and cinnamic acids showed similar effects as those found in the ARG treated group. Thus, it is suggested that ARG roots, ferulic acid, and cinnamic acid have hypoglycemic effects in an animal model. PRACTICAL APPLICATION: This study was conducted to elucidate the hypoglycemic effects of American red ginseng (ARG) using a type 2 diabetic mouse model. ARG showed an enhanced antioxidant capacity and higher antihyperglycemia effect. The glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. It is suggested that ARG has a potential to be used for human diabetic treatment.

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  • Publisher Full Text

    • Authors

    Yoo KM, Lee C, Lo YM, Moon B

    Institution

    Dept of Food and Nutrition, SoongEui Women's College, Seoul 100-751, South Korea. bkmoon@cau.ac.kr

    Source

    Journal of food science 77:7 2012 Jul pg H147-52

    MeSH

    Animals
    Blood Glucose
    Cinnamates
    Coumaric Acids
    Diabetes Mellitus, Type 2
    Disease Models, Animal
    Glutathione Peroxidase
    Glycogen
    Hypoglycemic Agents
    Insulin
    Lipid Peroxidation
    Lipoproteins, HDL
    Lipoproteins, LDL
    Male
    Malondialdehyde
    Mice
    Mice, Inbred Strains
    Panax
    Phytotherapy
    Plant Extracts
    Plant Roots
    Superoxide Dismutase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22757707