Abstract

Ectonucleotidases and the nucleotide metabolism have been implicated as important regulators in diabetes disease. We evaluated the ectonucleotidase activities and biochemical parameters in blood serum of streptozotocin (STZ)-induced diabetic rats submitted a physical training protocol. We observed a raise in ATP, ADP, AMP and p-Nph-5'-TMP hydrolysis rate and in the levels of cholesterol and triglycerides in rat blood serum, after 30 days of diabetes induction. However, in serum of rats submitted a physical training protocol by forced swimming, both the nucleotide hydrolysis rate and the lipids levels returned to the control values. Considering that diabetes leads to multiple pathophysiological alterations, the modulations observed in ectonucleotidase activities may be part of the events involved in these alterations. Then the physical training is a very important way to control the vascular alterations developed in diabetes.

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Authors

Moritz CE, Abreu-Vieira G, Piroli C, De Senna PN, Cardoso VV, Wink MR, Harthmann Âd, Rücker B, Casali EA

Institution

Laboratório de Bioquímica, Centro de Pesquisa e Pós-Graduação, Centro Universitário Metodista do IPA - Porto Alegre, RS, Brazil.

Source

Archives of physiology and biochemistry 118:5 2012 Dec pg 253-9

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22758792