A review on an update of NS5B polymerase hepatitis C virus inhibitors.
BACKGROUND: Hepatitis C virus (HCV) infection is widespread, abhorrently under-diagnosed, and radically under-treated. Globally, infection
with HCV is a major cause of acute hepatitis and chronic liver disease. Therefore, novel HCV inhibitors are required for the
treatment of the HCV infected patients.
PERSPECTIVES: This review gives the detailed knowledge of upcoming therapy such as NS5B polymerase inhibitors that are urgently needed.
CONCLUSION: In the past decade, intensive hard work has focused on the discovery of both structural and nonstructural inhibitors of the HCV NS5B polymerase. These demanding efforts have resulted in various promising agents advancing in clinical development with emphasis on clinical efficacy and impact for future combination studies.
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass Crossing, Delhi-Haridwar Highway, NH-58, Meerut, UP, India. firstname.lastname@example.org
SourceEuropean review for medical and pharmacological sciences 16:5 2012 May pg 667-71
Drug Resistance, Viral
Viral Nonstructural Proteins
Pub Type(s)Journal Article