Abstract

BACKGROUND
The objective of this study was to assess the impact of bariatric surgery performed in extremely obese non-diabetic subjects on the following parameters: endothelial function, inflammatory processes (assessed by high-sensitivity C-reactive protein [hs-CRP]), carotid artery intima-media thickness (CIMT), and glucose and lipid profiles.
METHODS
Forty-seven obese individuals with body mass index >40 kg/m(2) underwent bariatric surgery and returned for post-procedure assessment between 6 and 19 months after surgery. Ninety-three percent of patients were female. Their age ranged from 18 to 65 (mean 41) years old at baseline. Baseline was defined as the maximum of 30 days before surgery. Before and after surgery, all patients were subjected to a brachial artery ultrasound examination to evaluate endothelial-dependent dilation, CIMT by ultrasound, and laboratory analyses including glucose, lipid and inflammatory profiles were performed.
RESULTS
Subjects lost an average of 33 % of their original weight (p < 0.001). Flow-mediated dilation showed significant improvement after surgery from 7.4 % to 18.9 % (p < 0.001) on average. There was regression of CIMT, with the median being reduced from 0.8 to 0.5 mm (p < 0.001). The median Hs-CRP reduced from 0.83 to 0.18 mg/dl (p < 0.001), while glucose and lipid profiles were also improved after surgery.
CONCLUSIONS
This study shows that severely obese, non-diabetic patients who had pronounced weight loss after bariatric surgery had an overall improvement in brachial flow-mediated dilation, CIMT, high-sensitivity CRP, and glucose and lipid metabolism. The best responses of the brachial flow-mediated dilation after surgery were observed in non-smokers and in younger subjects.

Links

Publisher Full Text

Authors

Saleh MH, Bertolami MC, Assef JE, Taha MI, de Freitas W, Petisco AC, Barretto RB, Le Bihan DC, Barbosa JE, de Jesus CA, Sousa AG

Institution

Instituto Dante Pazzanese de Cardiologia, State of Sao Paulo - Health Secretary, Sao Paulo, Brazil. medsaleh@uol.com.br

Source

Obesity surgery 22:11 2012 Nov pg 1701-7

MeSH

Adolescent
Adult
Aged
Atherosclerosis
Bariatric Surgery
Biological Markers
Blood Glucose
Body Mass Index
Brachial Artery
C-Reactive Protein
Carotid Intima-Media Thickness
Female
Humans
Inflammation
Lipids
Male
Middle Aged
Obesity, Morbid
Treatment Outcome
Weight Loss
Young Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22777211