Abstract

BACKGROUND
Mid-regional pro-A-type natriuretic peptide (MRproANP) seems to be non-inferior compared to B-type natriuretic peptide (BNP) for heart failure diagnosis and prognosis; however, no previous studies have investigated the MRproANP in-hospital changes in prognostic role. This study aimed to compare the prognostic accuracy of BNP and MRproANP in-hospital changes in acute decompensated heart failure (ADHF) patients.
METHODS
37 patients with either admission/pre-discharge BNP and MRproANP data, were investigated. The combined endpoint was cardiovascular death/heart transplantation/readmission for HF.
RESULTS
BNP and MRproANP had a median decrease of 55% [72;45] and 21% [40; 11] respectively in event-free patients; BNP decrease of 34% [48; 29] but MRproANP increase of 4% [-7; 25] in patients with cardiovascular events. Prognostic accuracy of deltaBNP and deltaMRproANP was similar.
CONCLUSIONS
MRproANP basically trends up in patients with worse outcome and decreases in event-free patients, likely leading to a simpler interpretation although the prognostic accuracy is similar for both peptides.

Authors

Stenner E, Buiatti A, Barbati G, Merlo M, Sinagra G, Biasioli B

Institution

Department of Laboratory Medicine, A.O.U, Ospedali Riuniti di Trieste, Trieste, Italy. elisabetta.stenner@libero.it

Source

Clinical laboratory 58:5-6 2012 pg 585-9

MeSH

Acute Disease
Aged
Atrial Natriuretic Factor
Biological Markers
Female
Heart Failure
Humans
Length of Stay
Male
Natriuretic Peptide, Brain
Patient Discharge
Predictive Value of Tests
Prognosis
ROC Curve
Reproducibility of Results

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22783593