Abstract

Electrochemical oxidation of acyclovir at fullerene-C(60)-modified glassy carbon electrode has been investigated using cyclic and differential pulse voltammetry. In pH 7.4 phosphate buffer, acyclovir showed an irreversible oxidation peak at about 0.96V. The cyclic voltammetric results showed that fullerene-C(60)-modified glassy carbon electrode can remarkably enhance electrocatalytic activity towards the oxidation of acyclovir. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the acyclovir determination by differential pulse voltammetry. Effects of anodic peak potential (E(p)/V), anodic peak current (I(p)/μA) and heterogeneous rate constant (k(0)) have been discussed. Under optimized conditions, the concentration range and detection limit were 9.0×10(-8) to 6.0×10(-6)M and 1.48×10(-8)M, respectively. The proposed method was applied to acyclovir determination in pharmaceutical samples and human biological fluids such as urine and blood plasma as a real sample. This method can also be employed in quality control and routine determination of drugs in pharmaceutical formulations.

Links

Publisher Full Text

Authors

Shetti NP, Malode SJ, Nandibewoor ST

Institution

Department of Engineering Chemistry, K.L.E. Society's K.L.E. Institute of Technology, Hubli 580 030, India.

Source

Bioelectrochemistry (Amsterdam, Netherlands) 88: 2012 Dec pg 76-83

MeSH

Acyclovir
Antiviral Agents
Calibration
Carbon
Electrochemistry
Electrodes
Fullerenes
Glass
Humans
Oxidation-Reduction
Tablets
Time Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22796504