Abstract

OBJECTIVE
To compare the effect of zoledronic acid in treatment and prevention of osteoporosis with placebo.
METHODS
Random control trials regarding zoledronic acid in treatment of osteoporosis were retrieved by selecting Medline, EMbase and Pubmed databases till April 2012. The RevMan software was used for all of the statistical analysis.
RESULTS
A total of 9 trials were included in this meta-analysis. The pooled effect showed that zoledronic acid could increase the bone mineral density by 2.98 times compared with placebo, and reduce the rate of fracture in patients by 32%. The results should the zoledronic acid intervention had significantly less serious adverse events than controls, and the odds ratio was 0.81 (0.76-0.87). The longer term intervention, more than 12 months intervention, could gain a better prevention effect for osteoporosis (OR, 95%CI for BMD was 3.35, 2.77-3.92; for fracture was 0.67, 0.54-0.82).
CONCLUSIONS
This present study shows that zoledronic acid could be effective approach in the prevention of osteoporosis, and could increase the bone mineral density and reduce the risk of fracture.

Links

Publisher Full Text

Authors

Zhang J, Wang R, Zhao YL, Sun XH, Zhao HX, Tan L, Chen DC, Hai-Bin X

Institution

Department of Orthopaedics, the First Affiliated Hospital of Xinxiang Medical University, Weihui, PR China.

Source

Asian Pacific journal of tropical medicine 5:9 2012 Sep pg 743-8

MeSH

Aged
Bone Density
Bone Density Conservation Agents
Diphosphonates
Female
Fractures, Bone
Humans
Imidazoles
Infusions, Intravenous
Male
Middle Aged
Osteoporosis
Randomized Controlled Trials as Topic
Treatment Outcome

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

22805729