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Time course of changes in ocular wavefront aberration after administration of eye ointment.

Abstract

PURPOSE
To investigate the influence of an eye ointment on ocular aberration.
DESIGN
Prospective, comparative study.
METHODS
In 10 normal volunteers, ocular aberration was assessed before and 5, 30 min, 1, 2, 3, 6, and 12 h after administration of ofloxacin eye ointment. Ocular aberration was sequentially measured over a period of 10 s, and the root mean square (RMS) of the second-, third-, fourth-, and total higher-order aberrations (HOAs) were determined. From the sequential changes in total HOAs during 10 s, the fluctuation index (FI) and stability index (SI) were calculated. The obtained data were compared with those of another 17 normal volunteers who received timolol maleate gel-forming ophthalmic solution.
RESULTS
No significant changes in second-order RMS were observed after administration of the ointment. HOAs such as third-, fourth-, and total higher-order RMS significantly changed during the study period (P<0.05, repeated-measures analysis of variance). The RMS of each HOA component significantly increased 5 min after administration compared with the baseline values (P<0.05, Dunnett test). FI also increased significantly 5 min after administration (P<0.05), but SI did not change significantly. When compared with the results of the gel-forming solution group, HOAs and FI showed significantly higher values at several time points during 6 h after application (P<0.05, Mann-Whitney U-test).
CONCLUSIONS
Administration of eye ointment significantly degrades optical quality of the eye by increasing and oscillating HOAs. These changes were more pronounced than those after instillation of gel-forming ophthalmic solution for at least several hours.

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  • Publisher Full Text

    • Authors

    Hiraoka T, Yamamoto T, Okamoto F, Oshika T

    Institution

    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. thiraoka@md.tsukuba.ac.jp

    Source

    Eye (London, England) 26:10 2012 Oct pg 1310-7

    MeSH

    Aberrometry
    Adult
    Anti-Bacterial Agents
    Antihypertensive Agents
    Cornea
    Corneal Wavefront Aberration
    Female
    Humans
    Male
    Ofloxacin
    Ointments
    Prospective Studies
    Time Factors
    Timolol
    Visual Acuity

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    22814810