Abstract

BACKGROUND/AIMS
We investigated the clinicopathological findings and outcome after surgery for hepatocellular carcinoma in patients without hepatitis B or C virus infection.
METHODOLOGY
Among 562 patients who underwent curative resection for hepatocellular carcinoma, the sera from 97 patients (B group) were positive for hepatitis B surface antigen alone, sera from 355 patients (C group) were positive for anti-hepatitis C virus antibody alone and sera from 104 patients (NBNC group) were negative for both hepatitis B surface antigen and anti-hepatitis C virus antibody. We compared the clinicopathological findings and postoperative outcomes in the 3 groups.
RESULTS
The prevalence of diabetes mellitus, hypertension, hyperlipidemia and alcohol abuse were higher in the NBNC group than in the other groups. The prevalence of obesity was higher in the NBNC group than in the B group. Non-alcoholic steatohepatitis was detected in 16 NBNC patients. The tumor- free survival rate was higher in the NBNC group than in the C group.
CONCLUSIONS
Obesity, diabetes mellitus, hypertension, hyperlipidemia, alcohol abuse and non-alcoholic steatohepatitis were the possible risk factors for hepatocellular carcinoma in the NBNC group. The patients in the NBNC group are expected to show a better outcome as compared to patients in the C group.

Authors

Kaneda K, Kubo S, Tanaka H, Takemura S, Ohba K, Uenishi T, Kodai S, Shinkawa H, Urata Y, Sakae M, Yamamoto T, Suehiro S

Institution

Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. m1295277@msic.med.osaka-cu.ac.jp

Source

Hepato-gastroenterology 59:118 2012 Sep pg 1889-92

MeSH

Aged
Carcinoma, Hepatocellular
Comorbidity
Disease-Free Survival
Female
Hepatectomy
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis C
Hepatitis C Antibodies
Humans
Japan
Kaplan-Meier Estimate
Liver Neoplasms
Male
Middle Aged
Prevalence
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Tumor Markers, Biological

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22819910