Abstract

Nucleic acid delivery to cells to make them produce a desired protein or to shut down the expression of endogenous genes opens unique possibilities for research and therapy. During the last decade, to realize the potential of this approach, nanomagnetic methods for delivering and targeting nucleic acids have been developed, methods which are often referred to as Magnetofection. Our research group at the Institute of Experimental Oncology and Therapy Research, located at the University Hospital Klinikum rechts der Isar in the center of Munich, Germany, develops new magnetic nanomaterials and, their formulations with gene-delivery vectors and technologies to allow localized and efficient gene delivery in vitro and in vivo for a variety of research, diagnostic and therapeutic applications.

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Publisher Full Text

Authors

Plank C, Vlaskou D, Schillinger U, Mykhaylyk O

Institution

Institute of Experimental Oncology and Therapy Research, Klinikum rechts der Isar, Technical University Munich, Germany. plank@lrz.tum.de

Source

Therapeutic delivery 2:6 2011 Jun pg 717-26

MeSH

Adenoviridae
Gene Therapy
Gene Transfer Techniques
Genetic Vectors
Humans
Magnetic Fields
Metal Nanoparticles
Tissue Engineering

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22822504