Abstract

INTRODUCTION
Fracture healing is a complex process influenced by intrinsic and extrinsic factors. The aim of the present study was to evaluate the effects of botulinum toxin (BTX) A on fracture healing.
MATERIALS AND METHODS
Following the induction of bilateral standard closed femoral fractures and relative fixation in 18 Wistar albino rats, 8 IU of BTX A were injected into the right femoral region. After 28 days, all of the rats were sacrificed, the diameter of the callus was measured, and fracture healing was assessed by biomechanical and histopathologic evaluation.
RESULTS
While an increase in biomechanical and histopathologic healing was noted on the side injected with BTX A, a decrease in callus diameter was observed.
CONCLUSION
Botulinum toxin A administration increases the healing power in a relatively fixated fracture and decreases the callus diameter, just as if rigid fixation had been performed. The beneficial effect of BTX A on fracture healing might be associated with increased fixation rigidity.

Links

Publisher Full Text

Authors

Aydin A, Memisoglu K, Cengiz A, Atmaca H, Muezzinoglu B, Muezzinoglu US

Institution

Department of Orthopaedics and Traumatology, Izmit Seka State Hospital, Kocaeli, Turkey.

Source

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 17:6 2012 Nov pg 796-801

MeSH

Animals
Bony Callus
Botulinum Toxins, Type A
Femoral Fractures
Fracture Fixation
Fracture Healing
Injections, Intramuscular
Male
Neuromuscular Agents
Rats
Rats, Wistar
Weight-Bearing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22825767