Abstract

Hypertension and silent cerebrovascular lesions (SCL) detected by brain magnetic resonance imaging (MRI) are associated with an increased risk of cognitive decline. In a prospective observational study in 1000 hypertensive patients, aged 50-70 years, with no prior history of stroke or dementia, we will study the presence of mild cognitive impairment (MCI) and the relationship between SCL and cognition. All participants will be assessed by means of the Dementia Rating Scale-2 (DRS-2) and will undergo a brain MRI. In order to better characterize MCI and future dementia risk in our cohort, those patients that are suspected to be cognitively impaired according to the DRS-2 results will have a further neurological evaluation and complete neuropsychological testing. Follow-up for the entire cohort is planned to last for at least 3 years.

Links

Publisher Full Text

Authors

Riba I, Jarca CI, Mundet X, Tovar JL, Orfila F, Nafría C, Raga A, Girona A, Fernández-Lara P, Castañé X, Alvarez Sabin J, Fernández Cortiñas I, Maisterra O, Montaner J, Delgado P

Institution

Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain.

Source

Journal of the neurological sciences 322:1-2 2012 Nov 15 pg 79-81

MeSH

Aged
Brain
Cognition Disorders
Cohort Studies
Female
Humans
Hypertension
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Psychiatric Status Rating Scales

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22836018