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  • Links
  • Publisher Full Text
  • Authors
  • Kaelin WG
  • MESH
  • Algorithms
  • Animals
  • Gene Knockdown Techniques
  • Gene Targeting
  • Genes
  • High-Throughput Screening Assays
  • Humans
  • Mammals
  • Phenotype
  • RNA Interference
  • RNA, Small Interfering

Unbound MEDLINE

Molecular biology. Use and abuse of RNAi to study mammalian gene function.

Links

  • Publisher Full Text
  • Authors

    Kaelin WG

    Institution

    Department of Adult Oncology, Office M457, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. william_kaelin@dfci.harvard.edu

    Source

    Science (New York, N.Y.) 337:6093 2012 Jul 27 pg 421-2

    MeSH

    Algorithms
    Animals
    Gene Knockdown Techniques
    Gene Targeting
    Genes
    High-Throughput Screening Assays
    Humans
    Mammals
    Phenotype
    RNA Interference
    RNA, Small Interfering

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22837515

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    • RNA interference and the use of small interfering RNA to study gene function in mammalian systems.
    • Applications of RNA interference in mammalian systems.
    • Mammalian RNAi: a practical guide.
    • shRNA expression constructs designed directly from siRNA oligonucleotide sequences.
    • Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells.
    More
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