Regulating with Reg proteins: a new role in Th17 cell-mediated skin inflammation.
The mechanisms linking skin inflammation and observed defects in skin barrier function and integrity need further elucidation. In this issue of Immunity, Lai et al. (2012) identify REG3A as a downstream mediator of interleukin 17A that enhances keratinocyte proliferation and downmodulates keratinocyte differentiation.
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA. firstname.lastname@example.org
SourceImmunity 37:1 2012 Jul 27 pg 5-7