Abstract

Multiple sclerosis is a chronic disease requiring lifelong treatment with disease-modifying drugs that aim to prevent relapses and slow the progression of disability. The established first-line treatments for multiple sclerosis all require regular injections, and real-world observations suggest that long-term adherence to treatment is low. Indeed, poor adherence to disease-modifying drug treatment has been associated with poorer clinical outcomes. Autoinjectors have been developed to improve the success of self-injection, whilst also making injections more comfortable for patients, with the aim of minimizing obstacles to treatment adherence. RebiSmart™ is a new electronic autoinjector for subcutaneous administration of interferon β-1a (Rebif®) that includes several unique features designed to further reduce barriers to adherence, including a dosing log and adjustable comfort settings.

Links

Publisher Full Text

Authors

Devonshire VA, Verdun di Cantogno E

Institution

Department of Neurology, University of British Columbia, Rm S159, 2211 Wesbrook Mall, Vancouver V6T 2B5, BC, Canada. vdev@shaw.ca

Source

Therapeutic delivery 2:11 2011 Nov pg 1455-65

MeSH

Adjuvants, Immunologic
Equipment Design
Humans
Injections, Subcutaneous
Interferon-beta
Medication Adherence
Multiple Sclerosis
Self Administration

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22844681