Abstract

Many investigations have been devoted to determining the role of angiotensin II (ANG II) and aldosterone (ALD) in sodium-depletion-induced sodium appetite, but few were focused on the mechanisms mediating the salty taste changes accompanied with sodium depletion. To further elucidate the mechanism of renin-angiotensin-aldosterone system (RAAS) action in mediating sodium intake behavior and accompanied salty taste changes, the present study examined the salty taste function changes accompanied with sodium depletion induced by furosemide (Furo) combined with different doses of angiotensin converting enzyme (ACE) inhibitor, captopril (Cap). Both the peripheral and central RAAS activity and the nuclei Fos immunoreactivity (Fos-ir) expression in the forebrain area were investigated. Results showed that sodium depletion induced by Furo+low-Cap increased taste preference for hypertonic NaCl solution with amplified brain action of ANG II but without peripheral action, while Furosemide combined with a high dose of captopril can partially inhibit the formation of brain ANG II, with parallel decreased effects on salty taste changes. And the resulting elevating forebrain ANG II may activate a variety of brain areas including SFO, PVN, SON and OVLT in sodium depleted rats injected with Furo+low-Cap, which underlines salty taste function and sodium intake behavioral changes. Neurons in SFO and OVLT may be activated mainly by brain ANG II, while PVN and SON activation may not be completely ANG II dependent. These findings suggested that forebrain derived ANG II may play a critical role in the salty taste function changes accompanied with acute sodium depletion.

Links

Publisher Full Text

Authors

Lu B, Yan J, Yang X, Li J, Chen K

Institution

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, P R China.

Source

Regulatory peptides 179:1-3 2012 Nov 10 pg 15-22

MeSH

Aldosterone
Angiotensin I
Angiotensin II
Angiotensin-Converting Enzyme Inhibitors
Animals
Appetite
Appetitive Behavior
Body Weight
Captopril
Drug Combinations
Drug Evaluation, Preclinical
Furosemide
Immunohistochemistry
Male
Paraventricular Hypothalamic Nucleus
Radioimmunoassay
Rats
Rats, Sprague-Dawley
Renin-Angiotensin System
Sodium
Sodium Chloride, Dietary
Subfornical Organ
Supraoptic Nucleus
Taste

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22846885