In vitro synergism of simvastatin and fluconazole against Candida species.
Systemic fungal infections are responsible for high mortality rates. Several species of fungi may be involved, but Candida spp. is the most prevalent. Simvastatin is used to lower cholesterol and also exhibits antifungal action. The aim of this study was to evaluate the synergistic action of simvastatin with fluconazole against strains of Candida spp. Susceptibility testing was performed according to protocol M27-A3, by broth microdilution method and the synergistic effect of simvastatin and fluconazole was calculated based on FICI (Fractional Inhibitory Concentration Index). Eleven strains were evaluated, and simvastatin showed a synergistic effect with fluconazole against 10 (91%) of the Candida spp. strains tested. Simvastatin may be a valuable drug in the treatment of systemic infections caused by Candida spp.
Laboratory of Microbiology of Yeasts, Department of Clinical Analysis and Toxicology, College of Pharmacy, Federal University of Ceará, Fortaleza, CE, Brazil.
SourceRevista do Instituto de Medicina Tropical de São Paulo 54:4 2012 Aug pg 197-9
Microbial Sensitivity Tests
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't