Abstract

PURPOSE
The objective of the present study was to assess the effects of oriental sweet gum (Liquidambar orientalis Mill.) storax on partial-thickness and full-thickness wounds compared to conventional wound dressings in a porcine model.
METHODS
Six young Yorkshire pigs were used. Sixteen square excisional wounds measuring 3 × 3 cm were performed per animal. The wounds were allocated to one of the four treatment modalities: storax, hydrocolloid dressing, silver sulfadiazine, and control groups. Partial-thickness wounds were created in two pigs, and tissue samples were harvested on days 4 and 8, respectively. Full-thickness wounds were created in four pigs, and tissue samples were taken on days 4, 8, 14, and 21, respectively. Histologically, all wounds were examined for re-epithelialization and granulation tissue formation. Tissue hydroxyproline content and wound contraction areas were measured.
RESULTS
In storax-applied group, there was a greater depth of granulation tissue at 4 and 8 days compared to all other groups (p < .0125), and there was a faster re-epithelialization at 21 days compared to both hydrocolloid dressing and control groups in full-thickness wounds (p < .0125). Tissue hydroxyproline content and wound contraction did not differ significantly between the groups.
CONCLUSION
The results of this study indicate that topical application of storax enhanced both re-epithelialization and granulation tissue formation in full-thickness wounds. Further studies are indicated in this important area of wound healing research to evaluate the clinical efficacy of this storax and search for the mechanisms that explain its effects.

Links

Publisher Full Text

Authors

Ocsel H, Teke Z, Sacar M, Kabay B, Duzcan SE, Kara IG

Institution

Department of Plastic and Reconstructive Surgery, School of Medicine, Pamukkale University, Denizli, Turkey.

Source

Journal of investigative surgery : the official journal of the Academy of Surgical Research 25:4 2012 Aug pg 262-70

MeSH

Animals
Colloids
Epithelium
Granulation Tissue
Hydroxyproline
Liquidambar
Phytotherapy
Regeneration
Silver Sulfadiazine
Swine
Wound Healing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22853813