Unbound MEDLINE

Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men.

Abstract

Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.

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    • Authors

    Renström E

    Institution

    Lund University Diabetes Center, Inga-Marie Nilssons gata 53 floor 3, 205 02 Malmö, Sweden. erik.renstrom@med.lu.se

    Source

    Diabetologia 55:10 2012 Oct pg 2559-61

    MeSH

    Animals
    Glucose
    Homeostasis
    Humans
    Insulin
    Islets of Langerhans
    Pancreas
    Polymorphism, Single Nucleotide
    Transcription Factor 7-Like 2 Protein

    Pub Type(s)

    Comment
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22864463