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Neural and vascular responses to fused binocular stimuli: a VEP and fNIRS study.
PURPOSEThe aim of our study was to investigate the correlation between neural and hemodynamic responses to stereoscopic stimuli recorded over visual cortex.
METHODSTest stimuli consisted of a static checkerboard (checks) and dichoptic static random dot (RD) presentations with no binocular disparity (ZD) or with horizontal disparity (HD). Hemodynamic responses were recorded from right and left occipital sites using functional near-infrared spectroscopy (fNIRS). Visual evoked potentials (VEPs) were recorded over three occipital sites to the onset of the same stimuli.
RESULTSEarly components, N1 and P2, were sensitive to HD, suggesting that an enhanced N1-reduced P2 complex could be an indicator of binocular disparity and stereopsis. VEPs to checks and ZD stimulation were similar. fNIRS recordings showed changes in hemodynamic activation from baseline levels in response to all stimuli. In general, HD elicited a larger vascular response than ZD. Oxyhemoglobin concentration (HbO) was correlated with the VEP amplitude during the checks and HD presentations.
CONCLUSIONSWe report an association between neural and hemodynamic activation in response to checks and HD. In addition, the results suggested that N1-P2 complex in the VEP could be a neural marker for stereopsis and fNIRS demonstrated differences in HbO. Specifically, checks and HD elicited larger hemodynamic responses than random dot patterns without binocular disparity.
Investigative ophthalmology & visual science 53:9 2012 Aug pg 5881-9
Analysis of Variance
Evoked Potentials, Visual
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't