Abstract

A new high performance liquid chromatography (HPLC)-based method is proposed for the determination of vitamin E, free and in inclusion complexes with natural beta-cyclodextrin and its 2-hydroxy derivative. The method has been validated on the basis of the following parameters: specificity, selectivity, linearity, precision, range and recovery.

Authors

Gierlach-Hładoń T, Lange K

Institution

Department of Inorganic and Analytical Chemistry, Karol Marcinkowski University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.

Source

Acta poloniae pharmaceutica 69:4 pg 591-5

MeSH

Antioxidants
Calibration
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Drug Carriers
Drug Compounding
Hydrophobic and Hydrophilic Interactions
Reproducibility of Results
Sensitivity and Specificity
Solubility
alpha-Tocopherol
beta-Cyclodextrins

Pub Type(s)

Journal Article
Validation Studies

Language

eng

PubMed ID

22876599