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Diffuse alveolar haemorrhage in granulomatosis with polyangitis (Wegener's) with coexistent rheumatoid arthritis.

Abstract

Diffuse alveolar haemorrhage is a serious manifestation of granulomatosis with polyangitis (Wegener's) with high morbidity and mortality. It is defined by the clinical triad of haemoptysis, anaemia and progressive hypoxaemia. The diagnosis of granulomatosis with polyangitis is confirmed in an appropriate clinical setting by bronchoalveolar lavage, lung biopsy or detection of C-antineutrophil cytoplasmic antibodies. In this report, the patient was a known case of rheumatoid arthritis and presented with diffuse alveolar haemorrhage on CT scan; the underlying cause was found to be granulomatosis with polyangitis (Wegener's) with positive C-antineutrophil cytoplasmic antibodies. Despite aggressive treatment with immunosuppressants and steroids the patient died within a few days.

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  • Publisher Full Text
  • Authors

    Vaishnav KU, Bhatt C, Desai A

    Source

    BMJ case reports 2012: 2012 pg

    MeSH

    Adult
    Antibodies, Antineutrophil Cytoplasmic
    Arthritis, Rheumatoid
    Blood Sedimentation
    Fatal Outcome
    Female
    Hemoptysis
    Hemorrhage
    Humans
    Pulmonary Alveoli
    Respiratory Insufficiency
    Tomography, X-Ray Computed
    Wegener Granulomatosis

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    22878986