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Paneth cells and necrotizing enterocolitis.

Abstract

Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current animal models of NEC are limited in their capacity to answer these questions.

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    • Authors

    Underwood MA

    Institution

    Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, USA. mark.underwood@ucdmc.ucdavis.edu

    Source

    Gut microbes 3:6 pg 562-5

    MeSH

    Animals
    Disease Models, Animal
    Enterocolitis, Necrotizing
    Humans
    Infant, Newborn
    Infant, Premature
    Intestinal Mucosa
    Paneth Cells

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    22895084