Concomitant use of pazopanib and simvastatin increases the risk of transaminase elevations in patients with cancer.
Links
Authors
Xu CF, Xue Z, Bing N, King KS, McCann LA, de Souza PL, Goodman VL, Spraggs CF, Mooser VE, Pandite LN
Source
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 23:9 2012 Sep pg 2470-1MeSH
ATP-Binding Cassette TransportersAlanine Transaminase
Anticholesteremic Agents
Antineoplastic Agents
Clinical Trials as Topic
Drug Interactions
Drug-Induced Liver Injury
Humans
Hypercholesterolemia
Incidence
Neoplasm Proteins
Neoplasms
Polymorphism, Single Nucleotide
Pyrimidines
Reference Values
Simvastatin
Sulfonamides
Pub Type(s)
LetterResearch Support, Non-U.S. Gov't
Language
eng
PubMed ID
22918879
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