Abstract

OBJECTIVE
To compare the incidence of ectopic pregnancy (EP) after fresh ET and thawed ET.
DESIGN
Retrospective cohort study.
SETTING
Private fertility center.
PATIENT(S)
This retrospective study included 2,150 blastocyst transfers, including all 1,460 fresh autologous blastocyst transfers and all 690 transfers of autologous blastocysts derived from post-thaw extended culture of thawed bipronuclear oocytes in the 8-year study period 2004-2011.
INTERVENTION(S)
None.
MAIN OUTCOME MEASURE(S)
Visualized EP and treated persistent pregnancy of unknown location.
RESULT(S)
The rate of visualized EP was 1.5% in pregnancies in fresh autologous cycles, which was significantly more than the rate of 0 with autologous post-thaw extended culture. The rates of treated persistent pregnancy of unknown location were 2.5% and 0.3% in these two groups, respectively, a difference that was also statistically significant (relative risk 7.3, 95% confidence interval 1.7-31.0).
CONCLUSION(S)
Relative to fresh transfer, thawed ET was associated with significantly reduced incidence of EP. These findings are consistent with ovarian stimulation increasing the risk of EP.

Links

Publisher Full Text

Authors

Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C

Institution

Fertility Center of Las Vegas, Las Vegas, Nevada 89117, USA. bsshapiro@aol.com

Source

Fertility and sterility 98:6 2012 Dec pg 1490-4

MeSH

Adult
Cryopreservation
Embryo Transfer
Female
Fertility Preservation
Humans
Incidence
Middle Aged
Nevada
Pregnancy
Pregnancy, Ectopic
Risk Factors
Young Adult

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22925683