Abstract

OBJECTIVES
The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients with tumour necrosis factor receptor-associated periodic syndrome (TRAPS), in comparison to healthy controls, and to correlate their levels to parameters of disease activity and/or severity.
METHODS
Serum leptin, resistin, visfatin and adiponectin levels were obtained from 14 TRAPS patients carrying mutations involving cysteine residues, from 16 TRAPS patients carrying other mutations, and from 16 healthy controls. Demographic, clinical and laboratory parameters, including amyloidosis were entered for each patient. Comparisons between groups as well as reciprocal comparisons have been evaluated.
RESULTS
Serum leptin, resistin, visfatin and adiponectin did not significantly differ among the 3 groups. Patients carrying cysteine residues mutations showed lower visfatin serum levels than patients carrying other mutations (p<0.02). Serum leptin significantly correlated with the number of attacks/year (multiple R=0.32, multiple adjusted R2= 0.19, p <0.03). Serum adiponectin levels significantly correlated with the presence of amyloidosis (multiple R=0.79, multiple adjusted R2=0.57, p<0.03). Adiponectin values were a significant predictor for amyloidosis (AUC 0.75, 95 CI: 0.56-0.94, p<0.03), with a predicting cut-off value set at 23.16 pg/ml, the predictive positive value was 53.8%. Visfatin serum levels resulted respectively related to leptin (rs=0.42, r2=0.18, p<0.02) and to resistin (rs=0.57, r2=0.32, p<0.01) serum levels; whilst leptin and resistin serum levels did not reciprocally correlate.
CONCLUSIONS
Although a prospective design study and larger cohort are mandatory, adipokines serum levels and their correlations with parameters of disease activity and/or severity seem to show a baseline pattern in TRAPS patients.

Links

Publisher Full Text

Authors

Cantarini L, Obici L, Simonini G, Cimaz R, Bacarelli MR, Merlini G, Vitale A, Lucherini OM, Brizi MG, Galeazzi M, Fioravanti A

Institution

Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, 53100 Siena, Italy. cantariniluca@hotmail.com

Source

Clinical and experimental rheumatology 30:3 Suppl 72 pg S108-14

MeSH

Adiponectin
Adult
Aged
Amyloidosis
Analysis of Variance
Case-Control Studies
Cross-Sectional Studies
Cytokines
Disease Progression
Female
Genetic Predisposition to Disease
Hereditary Autoinflammatory Diseases
Humans
Leptin
Male
Middle Aged
Mutation
Nicotinamide Phosphoribosyltransferase
Phenotype
Receptors, Tumor Necrosis Factor, Type I
Resistin
Risk Assessment
Risk Factors
Severity of Illness Index
Young Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22935190