Abstract

SCOPE
The number of patients with chronic kidney disease (CKD) are increasing. Interventions such as controlling hypertension and specific pharmacologic options are recommended. Some nutraceutics may have benefits in this regard.
METHODS AND RESULTS
Naringenin (a flavanon), catechin (a flavanol), and quercetin (a flavonol) and rutin (a flavonol rutinoside) were tried on CKD in a Sprague Dawley rat model. Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-α, cleaved caspase-3, IκBα, PPARα, and serum insulin. But quercetin was only partially effective in restoring glomerular filtration rate, albuminuria, serum cholesterol, triglyceride, blood urea nitrogen (BUN), uric acid, malondialdehyde, superoxide dismutase; urinary BUN and urinary creatinine. As for signaling, quercetin was completely effective in alleviating the cleaved caspase-3, being only partially effective in suppressing Bax and Bad, restoring Bcl-2, and rescuing DNA damage.
CONCLUSION
The CKD status cannot to be ameliorated by naringenin, rutin, and catechin. Comparatively, quercetin may be a better therapeutic candidate.

Links

Publisher Full Text

Authors

Peng CC, Hsieh CL, Ker YB, Wang HY, Chen KC, Peng RY

Institution

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Source

Molecular nutrition & food research 56:10 2012 Oct pg 1541-58

MeSH

Albuminuria
Animals
Blood Urea Nitrogen
Caspase 3
Catechin
Cholesterol
Creatinine
Dietary Supplements
Doxorubicin
Flavanones
Glomerular Filtration Rate
In Situ Nick-End Labeling
Insulin
Kidney
Male
Malondialdehyde
Oxidative Stress
PPAR alpha
Quercetin
Rats
Rats, Sprague-Dawley
Renal Insufficiency, Chronic
Rutin
Superoxide Dismutase
Triglycerides
Uric Acid
bcl-2-Associated X Protein
bcl-Associated Death Protein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22945467