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Primary breast amyloidosis presenting solely as nonpalpable microcalcifications: a case report with review of the literature.

Abstract

Primary breast amyloidosis is a rare disease and usually occurs as unilateral or bilateral palpable masses. Primary breast amyloidosis presenting solely as microcalcifications is extremely rare. The authors report a case of a 73-year-old woman with persistent suspicious microcalcifications without palpable mass. The diagnosis was established by the presence of an amorphous and eosinophilic material that was positive for Congo red and dichroic under polarized light. Paraffin immunohistochemistry revealed the presence of kappa light chains (AL-type amyloidosis). The amyloid deposits were associated with microcalcifications. A complete work up was performed to exclude other localisations or associated pathologies and was negative. The primary breast amyloidosis is discussed and a review of the literature is presented.

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  • Publisher Full Text

    • Authors

    Ngendahayo P, Faverly D, Hérin M

    Institution

    Institut de Pathologie et Génétique (IPG), Gosselies, Belgium. placide.ngendahayo@ipg.be

    Source

    International journal of surgical pathology 21:2 2013 Apr pg 177-80

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22976248