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- Publisher Full Text
- Authors
- Bolmont T
- Bouwens A
- Pache C
- Dimitrov M
- Berclaz C
- Villiger M
- Wegenast-Braun BM
- Lasser T
- MESH
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Cerebral Amyloid Angiopathy
- Disease Models, Animal
- Fourier Analysis
- Humans
- Mice
- Mice, Transgenic
- Microscopy, Confocal
- Neuroimaging
- Plaque, Amyloid
- Staining and Labeling
- Tomography, Optical Coherence
Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy.
Abstract
We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended-focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β-amyloid plaques in the brain parenchyma and vasculature and requires no staining of the alzheimeric sample under investigation. xfOCM also opens the possibility to perform minimally invasive studies of β-amyloid pathology in vivo, without the use of labeling methods, which potentially confound experimental findings.
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Authors
Bolmont T, Bouwens A, Pache C, Dimitrov M, Berclaz C, Villiger M, Wegenast-Braun BM, Lasser T, Fraering PC
Institution
Laboratory of Molecular and Cellular Biology of Alzheimer's Disease, Brain Mind Institute and School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH1015 Lausanne, Switzerland.
Source
The Journal of neuroscience : the official journal of the Society for Neuroscience 32:42 2012 Oct 17 pg 14548-56MeSH
Alzheimer DiseaseAmyloid beta-Peptides
Animals
Cerebral Amyloid Angiopathy
Disease Models, Animal
Fourier Analysis
Humans
Mice
Mice, Transgenic
Microscopy, Confocal
Neuroimaging
Plaque, Amyloid
Staining and Labeling
Tomography, Optical Coherence
Pub Type(s)
Journal ArticleResearch Support, Non-U.S. Gov't
Language
eng
PubMed ID
23077040