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Epidemiological and microbiological characteristics of culture-proven acute otitis media in Taiwanese children.

Abstract

BACKGROUND/PURPOSE
Acute otitis media (AOM) is one of the most common diseases in children. Here, we describe the epidemiological and microbiological characteristics of AOM in Taiwanese children over a 10-year period.
METHODS
We retrospectively enrolled pediatric patients with culture-proven AOM who were treated at Mackay Memorial Hospital, Taipei between 1999-2008. The data include demographic characteristics, clinical history, and microbiological characteristics.
RESULTS
Six hundred and fourteen patients were included. The male:female ratio was 1.4 (p<0.001). Greater than three-fourths of the patients (476 [77.5%]) were < 5 years of age, and most patients were 1-2 years of age. The most common isolated pathogen was Streptococcus pneumoniae (419 patients [68.2%]), followed by nontypeable Haemophilus influenzae (NTHi; 118 patients [19.2%]). The distributions of age, gender, use of tympanocentesis, history of previous AOM, and use of antibiotic between patients infected with the two pathogens were not significantly different. However, the number of patients with AOM caused by S. pneumoniae, but not NTHi, decreased during the study period (p=0.004). Three hundred and eighty-seven children (63.0%) with AOM developed spontaneous otorrhea. Compared with patients who underwent tympanocentesis, those with spontaneous otorrhea were younger (27.0±16.4 vs. 31.1±15.2 months of age, p=0.004), more likely to have a previous history of AOM (p=0.019), and more likely to receive more antibiotics (p=0.012). The third most common pathogen was S. pyogenes (25 patients [4.1%]). S. pyogenes occurred more often in children > 5 years of age and was associated with spontaneous otorrhea (p<0.001).
CONCLUSION
S. pneumoniae and NTHi are common causes of culture-confirmed AOM in Taiwanese children. Although S. pyogenes is not as common, it usually causes AOM in children > 5 years of age and is associated with spontaneous otorrhea.

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  • Publisher Full Text
  • Authors

    Chiu NC, Lin HY, Hsu CH, Huang FY, Lee KS, Chi H

    Source

    Journal of the Formosan Medical Association = Taiwan yi zhi 111:10 2012 Oct pg 536-41

    MeSH

    Acute Disease
    Age Factors
    Anti-Bacterial Agents
    Child
    Child, Preschool
    Female
    Haemophilus Infections
    Haemophilus influenzae
    Humans
    Infant
    Male
    Otitis Media with Effusion
    Retrospective Studies
    Streptococcal Infections
    Streptococcus pneumoniae
    Taiwan

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23089688