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Serum lipids, proteins and electrolyte profiles in rats following total body irradiation.

Abstract

OBJECTIVE
Serum lipid and electrolyte imbalances are common in critically ill patients undergoing radiation therapy. Although multiple disease states and medication may be responsible for the development of these disorders, the aim of this research is to sequentially document the effect of total body radiation on body function utilizing the sequential changes in the serum lipids, electrolytes and protein in rats.
METHODS
Serum protein and lipids contents were assessed using kits while electrolytes were assessed with flame photometry in rats exposed to total body irradiations of 1.27 Gy/min in cumulative doses to the fourth irradiation at five-day intervals.
RESULTS
Total cholesterol and triacylglycerols serum levels were significantly reduced by irradiation (p < 0.05). No significant differences between experimental and control groups for HDL-C serum levels were detected. Serum electrolyte concentration remained within the normal range after each total body irradiation. Sodium, bicarbonate and chloride were significantly (p < 0.05) higher than control while potassium and creatinine were significantly reduced after the first irradiation only. Sodium/potassium ratio was significantly (p < 0.05) elevated. Serum protein was significantly (p < 0.05) elevated with increasing radiation.
CONCLUSION
There are subtle but significant changes in serum lipids, electrolytes and protein after total body irradiation of normal rats. These variations could be due to non-specific stress reactions; as such, they are important markers in radiation induced injury diagnosis.

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  • Authors

    Nwokocha CR, Nwokocha MI, Mounmbegna PP, Owu DU, Onyezuligbo O, Olu-Osifo EH, Okojie E, Asuquo E, Thaxter K, Ogunsalu C

    Source

    The West Indian medical journal 61:2 2012 Mar pg 117-21

    MeSH

    Animals
    Blood Proteins
    Electrolytes
    Lipids
    Male
    Rats
    Rats, Wistar
    Whole-Body Irradiation

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23155954