Unbound MEDLINE

Action of a toxic glycolipid of Corynebacterium diphtheriae on mitochondrial structure and function.

Abstract

The toxicity for mice of the cord factor of Cornebacterium diphtheriae, trehalose-6,6'-dicorynomycolate, was studied. The diphtherial cord factor showed a delayed lethal toxicity for mice; the median lethal dose was 120 mug. Mouse liver mitochondria were disrupted in vivo under the toxic action of the diphtherial cord factor into fragments deficient in both respiration and phosphorylation. The site of metabolic defect in the mitochondrial electron transport system was located at the region prior to the level of cytochrome c in the livers of cord factor-intoxicated mice. These effects of the diphtherial cord factor on the host-cell mitochondria were essentially similar to those of the cord factor of Mycobacterium tuberculosis, trehalose-6,6'-dimycolate.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors

    Kato M

    Source

    Journal of bacteriology 101:3 1970 Mar pg 709-16

    MeSH

    Animals
    Corynebacterium diphtheriae
    DNA
    Electron Transport Complex IV
    Glycolipids
    Injections, Intraperitoneal
    Lipids
    Male
    Mitochondria, Liver
    Oxidative Phosphorylation
    Oxygen Consumption
    Phosphorus
    Proteins
    Rats
    Succinate Dehydrogenase
    Succinates

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    4314542