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The accuracy of transvaginal ultrasonography in the diagnosis of endometrial abnormalities.

Abstract

OBJECTIVE
To evaluate the diagnostic accuracy of transvaginal ultrasonography for endometrial abnormalities in women with abnormal uterine bleeding.
METHODS
In a prospective study, 136 consecutive patients underwent transvaginal ultrasonography, hysteroscopy, and endometrial sampling through suction curettage or directed biopsy. The ultrasonographic findings were evaluated on the basis of the final diagnosis established by hysteroscopy and histologic examination. Receiver operating characteristic curve analysis and likelihood ratios were used. Likelihood ratios algebraically combine sensitivity and specificity to describe more than the independent values themselves, specifically the change in odds favoring disease given a particular test result.
RESULTS
In 21 of the 136 patients, hysteroscopy detected polyps or submucous myomas, which curettage failed to detect. In 67 premenopausal women, ultrasonography demonstrated a sensitivity in diagnosing endometrial abnormalities of 88% and a specificity of 68%, using a cutoff point of 5 mm of single-layer endometrial thickness. The positive likelihood ratio was 2.8 (95% confidence interval [CI] 1.66-4.55) and negative likelihood ratio 0.18 (95% CI 0.07-0.46). In 69 postmenopausal women, using a cutoff point of 3 mm, the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 97%, 74%, 3.7 (95% CI 2.18-6.38), and 0.04 (95% CI 0.01-0.28) respectively.
CONCLUSIONS
Transvaginal ultrasonography is an excellent first-step diagnostic method of excluding the endometrial abnormalities in women with postmenopausal bleeding but is of limited use in premenopausal women with irregular bleeding. Ultrasonography may reduce the number of invasive endometrial investigations by approximately 40%.

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  • Publisher Full Text
  • Authors

    Dijkhuizen FP, Brölmann HA, Potters AE, Bongers MY, Heinz AP

    Source

    Obstetrics and gynecology 87:3 1996 Mar pg 345-9

    MeSH

    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Endometrium
    Female
    Humans
    Middle Aged
    Postmenopause
    Predictive Value of Tests
    Premenopause
    Prospective Studies
    ROC Curve
    Sensitivity and Specificity
    Uterine Hemorrhage

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8598952