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Systematic review of Propionibacterium acnes resistance to systemic antibiotics.

Abstract

OBJECTIVE

To document changes in the prevalence of resistance of Propionibacterium acnes to antibiotics used for treating acne.

DATA SOURCES

MEDLINE and EMBASE were searched for publications on P. acnes resistance to systemic antibiotics. The search strategy mapped "acne" or "acne vulgaris" with the terms "antibiotic resistance" or "drug resistance, microbial". Only papers published in English during 1976 to 1997 were included in the search.

STUDY SELECTION

53 publications met the search criteria. The search output was refined by selecting papers that specifically addressed P. acnes resistance patterns. Additional studies (not included in the search output) were identified from review articles and references of the retrieved articles. Twelve articles were reviewed.

DATA EXTRACTION

Data on the prevalence of antibiotic-resistant propionibacteria, the incidence of individual resistance phenotypes, mixed resistance, and correlation between poor therapeutic response and resistant propionibacteria were extracted.

DATA SYNTHESIS

Research since 1978 has suggested an association between poor therapeutic response and antibiotic-resistant propionibacteria. The overall incidence of P. acnes antibiotic resistance has increased from 20% in 1978 to 62% in 1996. Resistance to specific antibiotics varied and was most commonly reported with erythromycin and clindamycin, tetracycline and doxcycline, and trimethoprim. Resistance to minocycline is rare.

CONCLUSIONS

In many patients with acne, continued treatment with antibiotics can be inappropriate or ineffective. It is important to recognise therapeutic failure and alter treatment accordingly. The use of long-term rotational antibiotics is outdated and will only exacerbate antibiotic resistance.

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  • Aggregator Full Text
  • Authors

    Cooper AJ

    Source

    The Medical journal of Australia 169:5 1998 Sep 7 pg 259-61

    MeSH

    Acne Vulgaris
    Drug Resistance, Microbial
    Gram-Positive Bacterial Infections
    Humans
    Propionibacterium acnes

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    9762064